The 2D10.4 antibody reacts with human CD80, a 60 kDa glycoprotein that is a member of the Ig superfamily. CD80, also known as B7-1, is a ligand for the T cell receptors CD28 and CTLA-4 (CD152). Along with CD86, CD80 plays a major role in regulating the activation of T cells. CD80 is expressed by activated antigen presenting cells including B cells, macrophages, and dendritic cells.
||In Vivo Ready™ Anti-Human CD80 (B7-1) (2D10.4)
||Mouse IgG1, kappa
||In Vivo Ready™
||Flow Cytometry, Functional Assays
||Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. 1991. J Exp Med. Sep1;174(3):561-569.
Freeman GJ, Gray GS, Gimmi CD, Lombard DB, Zhou LJ, White M, Fingeroth JD, Gribben JG, Nadler LM. 1991. J Exp Med. Sep 1;174(3):625-631.
Azuma M, Yssel H, Phillips JH, Spits H, Lanier LL. 1993. J Exp Med. Mar1;177(3):845-850.
Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. 1996. Immunity. Jun;4(6):535-543.
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.
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