The HIT2 antibody is specific for human CD38, a 45 kD type II transmembrane glycoprotein expressed on thymocytes, activated T and B cells, and monocytes as well as other non-hematopoietic cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.
|Name||violetFluor™ 450 Anti-Human CD38 (HIT2)|
|Isotype||Mouse IgG1, kappa|
|Citations*||Dianzani U, and Malavasi F. 1995. Crit. Rev. Immunol. 15(2):167-200.
Mehta K, Shahid U, and Malavasi F. Oct. 1996. FASEB J. 10(12):1408-1417.
Ferrero E, and Malavas F. Feb. 1999. J. Jeukoc. Biol. 65(2):151-161.
Matrai Z. Feb. 2005. Hematology. 10(1):39-46.
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.