The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.
The MAR-1 antibody is widely used both in flow cytometry and for depletion of cells in vitro / in vivo. Please choose the appropriate format for each application.
||Purified Anti-Mouse Fc epsilon Receptor I alpha (FceR1) (MAR-1)
||high affinity IgE receptor
||Armenian Hamster IgG
||Flow Cytometry, IHC, IP
||Mukai K, BenBarak MJ, Tachibana M, Nishida K, Karasuyama H, Taniuchi I, and Galli SJ. 2012. Blood. 120: 76-85. (Flow cytometry)
Smith KA, Harcus Y, Garbi N, Hammerling GJ, MacDonald AS, and Maizels RM. 2012. Infect. Immun. 80: 3481-3489. (in vivo depletion)
Larson D, Hubner MP, Torrero MN, Morris CP, Brankin A, Swierczewski BE, Davies SJ, Vonakis BM, and Mitre E. 2012. J. Immunol. 188: 4188-4199. (in vitro activation)
Khodoun M, Krishnamurthy D, Strait R, Kucuk Y, and Finkelman F. 2011. J. Immunol. 186: 151.4. (in vitro depletion)
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.
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