The SN5c antibody is specific for human CD10, a 100 kDa type II transmembrane protein also known as Common Acute Lymphoblastic Leukemia Antigen (CALLA). In normal cells, it is expressed on early B and T lymphoid precursors, neutrophils and on various epithelia. CD10 is also expressed on several lymphoma cells including Burkitt’s, acute lymphoblastic, and follicular germinal center lymphomas. CD10 functions as an endopeptidase and is involved in B cell development, as well as a mediator of neutrophil inflammatory responses.
||PE-Cyanine7 Anti-Human CD10 (SN5c)
||Common Acute Lymphocytic Leukemia antigen (CALLA), enkephalinase, Neprilysin, neural endopeptidase (NEP)
||Mouse IgG1, kappa
||Matsuzaki H, Haruta Y, Fukukawa T, Barcos MP and Seon BK. 1987. Cancer Res. 47(8): 2160-2166.
Shipp MA, Stefano GB, Switzer SN, Griffin JD and Reinherz EL. 1991. Blood. 78(7): 1834-1841.
Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y and Frenette PS. 2013. J Exp Med. 201(7): 1351-1367. (Flow cytometry)
Mukhopadhyay C, Zhao X, Maroni D, Band V and Naramura M. 2013. PLoS One. 8(10): e75907. (Flow cytometry)
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.
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