The RM2-5 antibody reacts with mouse CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD48 in the mouse and is expressed on the cell surface of all mouse lymphocytes. CD2 mediates adhesion between ≥ ≥ ≥ cells and is involved in T cell activation.
RM2-5 is reported to block CD2-mediated cell:cell adhesion. Please choose the appropriate format for each application.
|Name||PE Anti-Mouse CD2 (RM2-5)|
|Alternative Names||LFA-2, Ly-37|
|Isotype||Rat IgG2b, κlambda|
|Citations*||Yagita H, Nakamura T, Karasuyama H, Okumura K. 1989. Proc. Natl. Acad. Sci. 86(2):645-9.
Nakamura T, Takahashi K, Fukazawa T, Koyanagi M, Yokoyama A, Kato H, Yagita H, Okumura K. 1990. J. Immunol. 145(11):3628-34.
Criado G, Feito MJ, Rojo JM. 1996. Eur. J. Immunol. 26(6):1228-34.
Cibotti R, Punt JA, Dash KS, Sharrow SO, Singer A. 1997. Immunity. 6(3):245-55.
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications