The HB7 antibody is specific for human CD38, a 45 kDa type II transmembrane glycoprotein expressed on thymocytes, plasma cells, and monocytes as well as other non-hematopoietic cells. T and B lymphocyte expression is discontinuous and varies based on differentiation state – present on immature cells, low on intermediate stages, and high on activated mature cells. It is found on most CD34+ cells, but not on pluripotent stem cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.
|Name||PE Anti-Human CD38 (HB7)|
|Alternative Names||T10, ADP-ribosyl cyclase, cyclic ADP ribose hydrolase|
|Isotype||Mouse IgG1, kappa|
|Citations*||Tedder TF, Clement LT and Cooper MD. 1984. Tissue Antigens. 24(3): 140-149. (Flow cytometry)
Jackson DG and Bell JI. 1990. J Immunol. 144(7): 2811-2815.
Mahta K, Shahid U and Malavasi F. 1996. FASEB J. 10(12): 1408-1417.
Ferrero E and Malavasi F. 1999. J Leukoc Biol. 65(2): 151-161.
Llinas L, Lazaro A, de Saolrt J, Matesanz-Isabel J, Sintes J and Engel P. 2011. Immunol Lett. 134(2): 113-121. (Flow cytometry)
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.