The L17F12 antibody is specific for human CD5, a 67 kD transmembrane glycoprotein that is expressed on most thymocytes, mature T cells, and a subset of B cells. CD5 is a member of the scavenger receptor superfamily and is present on approximately 70% of normal peripheral blood lymphocytes. CD5 is involved in modulating antigen receptor signaling in both T and B cells and acts through binding of CD72, its receptor expressed on B cells.
||FITC Anti-Human CD5 (L17F12)
||Mouse IgG2a, κ
||Knapp W, Dorken B, et al. eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.
Gadol N and Ault KA. 1986. Immunol Rev. 93: 23-34.
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Raab M, Yamamoto M and Rudd CE. 1994. Mol Cell Biol. 14(5): 2862-2870.
Lydyard PM, Lamour A, MacKenzie LE, Jamin C, Magged RA and Youinou P. 1993. Immunol Lett. 38(2): 159-166.
McKenna RW, Washington LT, Aquino DB, Picker LJ and Kroft SH. 2001. Blood. 98(8): 2498-2507. (Flow Cytometry)
Butmarc JR, Kourea HP, Levi E and Kadin ME. 1998. Am J Clin Path. 109(6): 682-688. (Immunohistochemistry – paraffin-embedded tissue)
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.
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