The RPA-2.10 antibody reacts with human CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD58 in the human and is expressed on the cell surface of 80-90% of human peripheral blood lymphocytes, a subset of NK cells, and all mature T cells. CD2 mediates lymphocyte adhesion and is involved in T cell activation.
RPA-2.10 is reported to block mixed lymphocyte reaction. Please choose the appropriate format for each application.
|Name||FITC Anti-Human CD2 (RPA-2.10)|
|Alternative Names||LFA-2, T11, Sheep Red Blood Cell Receptor (SRBC-R), Ly-37|
|Isotype||Mouse IgG1, kappa|
|Cross Reactivity||Baboon, Chimpanzee, Cynomolgus, Capuchin Monkey, Rhesus, Pigtailed Macaque, Swine|
|Citations*||Knapp W, Dorken B, et al. eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.
Aversa GG, Bishop GA, Suranyi MG and Hall BM. 1987. Transplant Proc. 19: 277-278.
Hahn WC, Burakoff SJ, Bierer BE. 1993. J Immunol. 150(7):2607-2619.
Xu H, Elster EA, Blair PJ, Burkly LC, Tadaki DK, Harlan DM and Kirk AD. 2003. Am J Transplant. 3: 1350-1354. (Immunohistochemistry – frozen tissue)
Kim EO, Kim TJ, Kim N, Kim ST, Kumar V and Lee KM. 2010. J Biol Chem. 285: 41755-41764. (in vitro blocking)
Schernthaner GH, Jordan JH, Ghannadan M, Agis H, Bevec D, Nunez R, Escribano L, Majdic O, Willheim M, Worda C, Printz D, Fritsch G, Lechner K and Valent P. 2001. Blood. 98(13): 3784-3792. (Flow Cytometry)
Herodin F, Thullier P, Garin D and Drouet M. 2005. Eur Cytokine Netw. 16(2): 104-116. (Flow Cytometry – Baboon, Chimpanzee, Cynomolgus, Rhesus)
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.