The DATK32 antibody is specific for a combinatorial epitope of the mouse integrin αalpha 4/beta 7 (LPAM-1) heterodimer. LPAM-1 is expressed on most mature lymphocytes and sub-populations of thymocytes and bone marrow cells. It is involved in lymphocyte adhesion and migration and is a receptor for several extracellular matrix proteins including VCAM-1, fibronectin, and MAdCAM-1.
DATK32 is reported to induce LPAM-1 dependent lymphocyte aggregation and block adhesion to VCAM-1, fibronectin, and MAdCAM-1.
|Name||Biotin Anti-Mouse LPAM-1 (DATK32)|
|Isotype||Rat IgG2a, κ|
|Citations*||Andrew DP, Berlin C, Honda S, et al. 1994. J Immunol. 153(9):3847-3861.
Berlin C, Berg EL, Briskin MJ, et al. 1993. Cell. 74(1):185-195.
Bogetto L, Gabriele E, Cariati R, et al. 2000. Blood. 95:2397-2406.
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.