Description
Catalog No. T7766 CAS 1809249-37-3 Synonyms: GS-5734
Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
Biological Activity:
| Product Description:
Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells) |
| Receptor:
SARS-CoV; MERS-CoV; MHV; |
Chemical Information:
| Molecular Weight | 602.58 |
| Formula | C27H35N6O8P |
| CAS Number | 1809249-37-3 |
| Solubility |
DMSO: 125 mg/mL (207.44 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
| Storage | store at -80°C |
| Remark | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month. |
Technical Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.
Reference
- 1. Andrea J Pruijssers , et al. Nucleoside analogues for the treatment of coronavirus infections[J]. Curr Opin Virol. 2019 Apr;35:57-62.
- 1. Agostini M L , Andres E L , Sims A C , et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease[J]. Mbio, 2018, 9(2):e00221-18.
- 2. Momattin H , et al. A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)[J]. Travel Med Infect Dis. 2019 Jul – Aug;30:9-18.
- 2. Wang M , Cao R , Zhang L , et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro[J]. cell research.
Additional information
| Size | 1 mg, 5 mg, 10 mg, 1 mL * 10 mM (in DMSO) |
|---|