Cell therapy is a therapeutic approach by administering viable cells into patients to replace or repair damaged cells and/or tissues. Bone marrow transplant (hematopoietic stem cell transplant) was the first successful cell therapy to effectively treat blood cancers and hematopoietic diseases. Since then, various cell types have been developed for treatments of various diseases as a part of regenerative medicine. These include retinal repair, Parkinson’s disease, wound healing and diabetes, which are still in early clinical stages.
There are two main types of cell therapy strategies: (i) Allogeneic transplant – where the donor is a different person to the recipient, (ii) Autologous transplant – where the transplanted cells are derived from the patient’s own tissues. The success of the treatment has been established using either stem cells or differentiated cells including hematopoietic stem cells, induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), CAR-T cells and NK cells.
iPSCs are human embryonic stem cells (hESCs)-like cells derived from fibroblast cells. Currently, applications of iPSCs were used as disease modelling and drug screening. It can be differentiated to replace defective cells and tissues such as cardiac and neural cells. MSCs are multipotent stem cells that can differentiate into several cell types. MSCs are potent in immunomodulatory capacity and cytokine secretion which make them suitable for graft-versus-host disease (GvHD) and tissue regeneration. Chimeric antigen receptor (CAR) T-cell therapy is a type of immunotherapy that modifies a person’s immune system to target the cancer cells. CAR-T cells are engineered T cells to produce an artificial T cell receptor targeting the specific antigen on cancer cells. NK cells are body’s first line of defense. In NK cell therapy, human peripheral blood mononuclear cells were isolated and subjected to antibody and cytokine stimulation ex vivo, which result in NK cell activation and proliferation. Activated NK cells were then infused into the patient targeting the cancer cells.
Our goal is to support you at every stage of your stem cell / cell therapy development. Streamline your research with our cell culture solutions – CellCor chemically defined media (GMP grade) for MSC, Alpha STEM Naïve hPSC media for iPSC, human platelet lysates, human serum AB, recombinant human serum albumin, recombinant laminin for substrate for cell culture, GMP Grade recombinant proteins / growth factors, and Atlantis NK activation and expansion kit for NK cell therapy. Atlantis Bioscience also provides consultation services by our specialists to ensure GMP cell manufacturing from initial to standardization with standard processes to gain excellence in cell therapy workflow.