Discover the ideal microenvironment for your application.
We provide you with the ideal tool to rapidly test a large variety of cell microenvironments at once. denovoMATRIX technology allows us to incorporate the most important biological ligands for cell adhesion, spreading and robust growth within our biomimetic coatings. We have compiled 96 coating compositions which represent 96 different microenvironments in the screenMATRIX which is ready to use without any preparation. All you need to do is seed your cells on the screenMATRIX and discover which coating(s) works best. Check out our screenMATRIX infosheet to find out exactly which biological ligands are responsible for your optimal cell response.
How do i store screenMATRIX plates?
-The screenMATRIX can be stored at room temperature for the maximum of one year. Ensure it is protected from direct sun light.
Do denovoMATRIX coatings contain proteins?
–No, denovoMATRIX coatings do not contain proteins of any kind. denovoMATRIX coatings are composed of polymers, sulfated polysaccharide, and synthetic protein fragments known as peptides. We use peptide sequences, which are derived from human proteins with a biological function in the extracellular matrix.
My cells do not attach to the coatings. What should i do?
-Cell attachment behavior is very different depending on cell type, varying from 30 minutes to several hours. First step would be to check what is considered ‘normal’ for your cell type. Next, make sure you have safely deactivated your cell dissociation reagent (such as trypsin or dispase) before adding the cell suspension to the coated surfaces. Washing and centrifuging your cells may help to remove any traces of leftover cell dissociation reagent. Addition of growth factors and other soluble signaling molecules might be necessary to increase cell survival and attachment after passaging.
-Yes, denovoMATRIX coatings are compatible with multiple stains. In case you run into issues with a particular stain on our coatings please contact us.
How many replicates are normally necessary?
-Each screenMATRIX offers 96 different compositions. A minimum of 3 experimental replicates are recommended, which is equal to 3 screenMATRIX plates. The total number of necessary replicates may vary however, based on cell type or the sensitivity of your assay.
How is the quality control done?
-The components of the screenMATRIX are routinely subject to quality analysis. Each production batch of screenMATRIX plates is controlled for the ability to provide attachment to human mesenchymal stromal cells and mouse neural precursor cells.
Is there a discount for bigger orders?
-denovoMATRIX is happy to serve individual requests.
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