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The benefits of Biogelx™ hydrogel technology

1) REPRODUCIBLE

Our hydrogels are fully synthetic and prepared in our dedicated manufacturing facility to high-level quality control standards ensuring no batch-to-batch variations. Such consistency is key for applications such as drug screening and regenerative medicine where reproducible results are critical.

2) MECHANICALLY TUNEABLE

Biogelx™ hydrogels can generate a broad range of matrix stiffness, from 0.5 kPa up to 100 kPa, which is simply controlled through variation in peptide concentration. This offers the user the opportunity to;

  • Tailor the stiffness of the gel to match the mechanical properties of specific tissue types. Thereby providing an optimal environment for the culture of a variety cell types.
  • Develop more physiologically relevant disease models. It is known that tissues stiffen during ageing and pathological progression of disease e.g. cancer, fibrosis. Being able to mimic these stiffness changes with a single material allows researchers to model disease progression more effectively.
  • Control stem cell behaviour. With the ability to control matrix stiffness, our hydrogels can aid stem cell migration, differentiation, survival, and integration. The stiffness of the gel matrix dictates cell fate, with soft gels favouring differentiation towards soft tissue cells (e.g. neuronal, adipose) and rigid gels favouring differentiation towards stiff tissue lineages (e.g. bone, cartilage).

3) EAST TO USE

Our hydrogel products are shipped as a lyophilised powder which means an extended shelf life, simple handling, and greater flexibility to tailor the gels to your requirements.

When the Biogelx™ powder is added to water, the peptides self-assemble to form fibers producing what is known as a “pre-gel” solution. This pre-gel has a cell-friendly neutral pH, and it is at this stage that cells can be encapsulated for 3D cell culture techniques. It is only when this pre-gel solution comes in contact with divalent cations (e.g. Ca 2+) in cell culture media that gelation take place to form the final gel. The gelation process is triggered in a controlled manner, with no pH or temperature requirements. As such, the materials are amenable to a huge variety of handling techniques, can be used in standard 2D/3D well plate formats (384–6 well), are compatible with automated liquid handling systems, and are injectable.

Our powder format allows easy incorporation of application-specific proteins, growth factors, or other bioactive molecules e.g. drug molecules into the hydrogels.

4) BIOMIMETIC FUNCTIONALITY

Biogelx™ hydrogels incorporating biomimetic peptide sequences provide improved cell attachment and interactions between cells and the matrix compared with other traditional synthetic polymer scaffolds whilst still retaining the control and predictability expected of synthetic materials.  Biogelx has demonstrated good biocompatibility and cell growth across a range of cell types including, stem cells, neuronal, cancer, skin, and cartilage.

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2°C ~ 8°C Pharmacy/Lab Refrigerators

YC-55L/75L

• Smart under-counter size
• Intelligent Control & Constant Temperature
• Multiple alarms bring more security

2°C ~ 8°C Medical Refrigerators

YC-400L

Brand new product
• Seven sensors
• Temperature uniformity
• Ensuring safety of storage

Please contact us for quotation:
sale@atlantisbioscience.com

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Featured Products

All Products

ReZolve-ER on plasma membrane

ReZolve-ER™
ReZolve-ER™ is a live cell imaging agent with rapid cell uptake for imaging the endoplasmic reticulum. For use in a wide variety of live and fixed cells.
IraZolve-ER Blue™

IraZolve-ER Blue™ localises to the endoplasmic reticulum in live and fixed cells. It is highly cell permeable, producing quick and reliable cell staining. IraZolve-ER Blue™ can detect the endoplasmic reticulum following anti-body staining protocols and is compatible with a range of fluorescence systems.


ReZolve-L1™
ReZolve-L1™ is a cell-permeant stain with an affinity for polar lipids which can be used in a wide variety of live and fixed samples. ReZolve-L1 provides excellent and rapid lipid staining used for fluorescent microscopy applications and automated imaging. This stain is an effective tracer of lipids (e.g. cholesterol, sphingolipid and phospholipid) and intracellular localisation.


IraZolve on H9c2 cells

IraZolve-L1™

IraZolve-L1™ is a cell-permeant stain that localises with polar lipids and can be used in a wide variety of live and fixed cells. IraZolve-L1™ provides excellent and rapid lipid staining, localising with lipid droplets and the endoplasmic reticulum in cultured cells useful for fluorescent microscopy applications.

  • IraZolve-Mito image
    IraZolve-Mito™

    IraZolve-Mito™ is a specialised live cell imaging agent with rapid cell uptake for mitochondria. IraZolve-Mito™ can be used for effective staining of mitochondria in live and fixed tissues.

    ReZolve-Alkyne™

    A cell permeable luminescent alkyne with large Stokes shift, long emission life time and is resistant to photobleaching. Can be conjugated to a range of biological and non-biological chemicals for flexible applications.


    BaseClick EdU Kits
    ReZolve Scientific has been appointed BaseClick distributor for Australia and New Zealand.  BaseClick Edu kits are compatible with all ReZolve fluorophores.
Properties ReZolve-L1 IraZolve-Mito ReZolve-ER IraZolve-L1 ReZolve-Alkyne
Localisation Polar Lipids Mitochondria Endoplasmic
Reticulum
Lipid droplets &
endoplasmic reticulum
User defined
luminescent tag
Colour Yellow Red Orange Red Orange
Resistance to
photo bleaching
High High High High High
Cytotoxicity Low Low Low Low Low
Ex / Em UV or
450nm/550nm
405nm/600nm UV or
405nm/570nm
405nm/600nm UV or
450nm/550nm
For live cells and tissue Yes Yes Yes Yes Yes
For fixed cells and tissues Yes Fixed tissue only Yes Yes Yes
Solubility DMSO DMSO DMSO DMSO DMSO
For Fluorescence and
Multiphoton Microscopy
Yes Yes Yes Yes Yes
For Raman and
Infrared Spectroscopy
Yes No Yes No Yes
Storage and Transport Room Temp Room Temp
(4oC post reconstitution)
Room Temp Room Temp Room Temp
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Key Features:

> Fast and easy to use compact imager

> Saves time in the dark room developing film.

> Load, capture images, manage data acquisition and analysis with the touch of a finger, driven by Windows OS.

> Captures high resolution images with the same sensitivity as film or even better.

> Direct short distance from the sample to the detector with no bends, no mirrors, maximizes light-collection for reliably sensitive imaging.

> Single, multi-functional imager that can quantify all of your gels and blots—DNA, protein, colorimetric and photometric

 

Two blots of serially diluted HRP-coupled secondary antibodies were prepared on nitrocellulose. Both blots were treated with a substrate. Left: Imaged on Azure cSeries for 2minutes. Right: Imaged on film for 2 minutes.

C300

  • Chemi, UV, White Light, Blue Light
  • Upgradeable to cSeries 400-600
  • Sensitive Detection of Proteins with Chemiluminescent Westerns
  • UV and blue-Excited DNA Dyes, Coomassie gel imaging and More
  • Compact design—with a footprint of 38cm W X 55cm H X 36cm D,
  • 4.8 OD Dynamic Range

C400

  • RGB, Chemi, UV, White Light, Blue Light
  • Upgradeable to c600
  • Sensitive Detection of Proteins with Chemiluminescent Westerns
  • UV and blue-Excited DNA Dyes, Coomassie gel imaging and More
  • Three channel RGB excitation for Cy5/Cy3/Cy2 applications—allows quantitation of two proteins (or modifications) and a loading control without stripping and re-probing
  • 4.8 OD Dynamic Range

Apply for c400,

RGB LEDs Colored LEDs provide robust excitation for quantitative visible fluorescence imaging, with excitation at 460, 526, and 628 nm for Cy2/Cy3/Cy5 or similar dyes.

 

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Fast and Accurate Image-Based
Cell Counting with Autofocusing

Facscope™ is the automatic image-based cytometer equipped
with fully motorized X-Y-Z stage, autofocusing and best-in-class
image processing technology for fast and accurate counting results.
We provide the cost saving 4-channel test slides and image analysis
software for deeper research.

Key Features

> Accurate cell counting by Trypan blue
> Multi frame image analysis
> Auto-focusing (no manual focusing required)
> Supporting gating function for cell size analysis
> Dynamic range of 5×104 ~ 1×107 cells/mL
> Compatible with biosafety cabinet
> Fast and accurate measurement

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Dear valued customers,

We are happy to represent Vale Life Sciences to provide unique and innovative technologies for use in medical and drug discovery research.

Our products and tools are designed to improve the reproducibility and relevance of invitro cell and tissue based experimental models.

Developed to improve research outcomes by:

  • Increasing experimental reproducibility
  • Improving biological relevance
  • Significantly reducing costs
  • Being simple and easy to use

 

Our technologies:

  • Are designed to work seamlessly with automated systems
  • Do not require expensive capital outlay
  • Are compatible with all conventional laboratory equipment

 

Research applications include:

  • Oncology & Chronic Disease Models
  • Stem Cell Culture
  • Primary Cell Culture and Expansion
  • Flow Cytometry
  • Biosensors
  • Microscopy and High Content Imaging

 

Our mission is to provide high quality, robust, and innovative research tools to sustain the current and future needs of the scientific community.

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Foetal bovine serum or Foetal Calf serum is a product derived from fetuses of bovine. No manufacturer can control the content or concentrations of each component in the bovine source.

As raw serum is in huge demand, some manufacturers have been caught adulterating the product or falsifying production documents in order to keep up with the demand.

This creates huge problems for the research community where results are simply not reproducible.

So what is inside your FBS? Find out more at sales@atlantisbioscience.com

 

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Denova Life Science’s patented DNSkin™  system  is three dimensional cellular system of ASIAN human epidermal keratinocytes for in vitro testing. A leading system in Singapore; it has proven to be an excellent tool to examining various chemical pharmaceutical and skin care applications.

Do contact us at sales@atlantisbioscience.com to have a free consultation. Or kindly download their corporate Company brochure

 

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